Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis

Radiation Oncology

Table 1 Transformation frequencies of unirradiated or irradiated cells differing in the status of Atm and Brca1.

Genotype	Dose (Gy)	Total number of clones scored	Number of transformed clones	Transformed clones (%)
Atm wt/Brca1 wt	0 Gy	31220	7	0.02
	2 Gy	21880	26	0.12
Atm wt/Brca1 hz	0 Gy	34380	11	0.03
	2 Gy	17142	32	0.19
Atm hz/Brca1 wt	0 Gy	34170	11	0.03
	2 Gy	16720	36	0.21
Atm hz/Brca1 hz	0 Gy	26660	9	0.04
	2 Gy	12046	27	0.22

ISSN: 1748-717X