Toxicity Grade | During a Course of Therapy | Dose for Next Cycle | |
---|---|---|---|
Grade 1 | Â | Maintain dose level# | Maintain dose level |
Grade 2 | 1st appearance | Interrupt until resolved to grade 0-1 | Maintain dose level |
 | 2nd appearance | Interrupt until resolved to grade 0-1 | 400 mg every day |
 | 3rd appearance | Interrupt until resolved to grade 0-1 | 400 mg every the other day |
 | 4th appearance | Discontinue treatment permanently |  |
Grade 3 | 1st appearance | Interrupt until resolved to grade 0-1 | 400 mg every day |
 | 2nd appearance | Interrupt until resolved to grade 0-1 | 400 mg every the other day |
 | 3rd appearance | Discontinue treatment permanently |  |