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Table 1 Patient characteristics, outcome and genetic information

From: Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome

  1 2 3 4 5 6 7 8
Age 27 32 22 32 22 29 48 39
Histology DCIS IDC and DCIS IDC IDC Phyllodes sarcoma IDC IDC DCIS
Grade NA 1 NA 2 NA 2 3 NA
Hormonal receptor UN pos pos pos NA pos pos pos
HER2 overexpression NA neg pos pos NA neg neg NA
TNM TisN0M0 T1N0M0 T2N1M0 T1N1M0 TxN0M0 T1N1M0 T4N1M0 TisN0M0
Adjuvant Radiotherapy No No Yes Yes Yes Yes Yes Yes
Local relapse No No No No Yes Yes No Yes
Contralateral breast cancer No Yes No Yes Yes Yes No No
Radio induced tumors No No No No Yes No * Yes
New primary outside RT field No No No No Yes No No Yes
c.375G > C exon 4
splice site
c.844C > T
exon 8 missense
c.742C > T
exon 7 missense
c.467G > A
exon 5
c.724T > C exon 7
c.542G > A
exon 5 missense
c.524G > A
exon 5 missense
c.673-2A > G
intron 6
splice site
  1. DCIS: ductal carcinoma in situ; IDC: invasive ductal carcinoma; UN unknown; NA: non applicable; * in field tumor with atypical histology