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Table 4 Univariate and multivariate analyses for disease-free survival (DFS) and local recurrence-free survival (LRFS) with combined CA12/Differentiation parameters in 173 patients with cervical cancer following radiotherapy

From: Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

Combined Categories of CA12 and histologic differentiation

DFS

LRFS

Category

Combination

HR (95% CI) Univariate Multivariate*

p value Univariate Multivariate*

HR (95% CI) Univariate Multivariate*

p value Univariate Multivariate*

1(N = 81)

CA12(-)/WD,

1 (Ref)

 

1 (Ref)

 
 

CA12(+)/WD, MD

1 (Ref)

 

1 (Ref)

 

2(N = 65)

CA12(+)/PD

1.81 (0.96-3.39)

0.07

2.28 (0.76-6.80)

0.14

 

CA12(-)/MD

1.82 (0.96-3.46)

0.07

3.01 (0.96-9.40)

0.06

3(N = 27)

CA12(-)/PD

3.62 (1.76-7.41)

< 0.01

5.94 (1.94-18.17)

< 0.01

  

2.82 (1.32-6.04)

< 0.01

5.80 (1.61-20.98)

< 0.01

  1. Ref: Reference value; HR: hazard ratio; PD: poorly differentiated; MD: moderately differentiated; WD: well differentiated
  2. *adjusted for age group, FIGO stage, tumor size, and pathological type