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Table 1 Clinical evaluation of DAO and the measures used in plan comparison.

From: Direct aperture optimization as a means of reducing the complexity of intensity modulated radiation therapy plans

Author

Year

Participant numbers

Measures used in plan evaluation

Van Asselen et al. [20]

2006

12 breast cancer patients

• V95 & V105 of TV

• D99 & DD01 to measure homogeneity within TV

• Dmax to heart

• Mean dose of both lungs

Ahunbay EE et al. [19]

2007

15 breast cancer patients

• Uniformity index

• Global uniformity index

• V20 lung

• V25 heart

Dobler et al. [22]

2007

10 hypopharyngeal patients

• Absolute values for DVH points which violated the Dose volume objectives(DVO).

• D95 & D5 of PTV

• V95 & VV107 of PTV

• Daverage

• Dose homogeneity measured by (D5–D95)/Daverage

• D50 to parotid gland

• Dmax spinal cord

Jones S et al. [21]

2008

11 head and neck patients

• Composite objective value i.e. the weighted sum of al the objective values

• Conformity index

Ludlum E et al. [17]

2008

5 prostate and 5 nasopharynx patients

• V95-tumouir coverage

• Multiple defined endpoints for sensitive structures

• Conformity index

• Homogenity index

• Delivery time