Tumor volume and survival in mice with subcutaneous U87 MG xenografts treated with MP470 and radiation. Tumor volume of 1,500 mm3 was used as a baseline for calculating tumor growth delays, and mice were euthanized once they reached 2000 mm3. (A) Irradiation alone resulted in a modest AGD of 6.1 ± 2.3 days, while the combination of MP470 plus irradiation produced an AGD of 17.7 ± 2.8 days, resulting in an enhancement ratio of 2.9 (Table 1). (B) Kaplan-Meier survival rates on day 48 (the final day of the experiment) were 0% in both the control and MP470-alone groups, 50% in the radiation-only group (P = 0.035), and 87.5% in the MP470 + radiation group (P = 0.001). Each data point represents the mean of 8 tumors; bars indicate standard error.