Figure 7From: The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cellsTumor volume and survival in mice with subcutaneous U87 MG xenografts treated with MP470 and radiation. Tumor volume of 1,500 mm3 was used as a baseline for calculating tumor growth delays, and mice were euthanized once they reached 2000 mm3. (A) Irradiation alone resulted in a modest AGD of 6.1 ± 2.3 days, while the combination of MP470 plus irradiation produced an AGD of 17.7 ± 2.8 days, resulting in an enhancement ratio of 2.9 (Table 1). (B) Kaplan-Meier survival rates on day 48 (the final day of the experiment) were 0% in both the control and MP470-alone groups, 50% in the radiation-only group (P = 0.035), and 87.5% in the MP470 + radiation group (P = 0.001). Each data point represents the mean of 8 tumors; bars indicate standard error.Back to article page