Figure 3
From: Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model
(a) Photomicrographs of H&E stained mouse lung tissue sections from a) control mice, b) irradiated mice (20 Gy, RT) and mice treated with imatinib starting 3 days (c) or 2 weeks (d) after thoracic irradiation. Leukocytes infiltration was marked with asterisk. (b) Photomicrographs of H&E stained mouse lung tissue sections at 16 weeks from a) control mice, b) irradiated mice (20 Gy, RT) and mice treated with imatinib starting 3 days (c) or 2 weeks (d) after thoracic irradiation. Fibroblasts were marked with arrow. (c) Photomicrographs of H&E stained lung tissue sections at 20 weeks from a) control mice, b) irradiated mice (20 Gy, RT) and mice treated with imatinib starting 3 days (c) or 2 weeks (d) after thoracic irradiation. Collagen depositions were marked with #.