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Table 1 Comparison of single versus split dose irradiation with or without concomitant chemotherapy

From: The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

Treatment

Crypt count (95% CI)

p-value

5 Gy

101 (99-103)

< 0.0001

2 × 2.5 Gy

114 (111-116)

 

5 Gy + 5-FU

80 (66-95)

< 0.0001

2 × 2.5 Gy + 5-FU

102 (94-111)

 

5 Gy + oxa

101 (94-108)

0.5

2 × 2.5 Gy + oxa

102 (91-112)

 

5 Gy + 5-FU + oxa

88 (77-98)

0.007

2 × 2.5 Gy + 5-FU + oxa

93 (75-111)

 

7.5 Gy

54 (29-80)

< 0.0001

3 × 2.5 Gy

99 (93-107)

 

7.5 Gy + 5-FU

39 (20-58)

< 0.0001

3 × 2.5 Gy + 5-FU

95 (81-110)

 

7.5 Gy + oxa

23 (15-31)

< 0.0001

3 × 2.5 Gy + oxa

91 (84-99)

 

7.5 Gy + 5-FU + oxa

29 (0-57)

< 0.0001

3 × 2.5 Gy + 5-FU + oxa

97 (91-103)

 
  1. 5-FU dose = 50 mg/kg, oxaliplatin dose = 6 mg/kg
  2. Abbreviations: oxa = oxaliplatin
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Radiation Oncology

ISSN: 1748-717X

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