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Table 4 Results of repeated measures ANOVA about the changes of mean TGF-β1 level during the course of radiation therapy

From: The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients

 

Mean ± SD (× 104 pg/ml)

Repeated measures ANOVA

 

Before RT

Beginning of RT

Middle of RT

End of RT

2 wks after RT

4 wks after RT

Source

F

p value

RP1

(n = 17)

2.8 ± 0.8

2.4 ± 0.7

2.0 ± 0.6

2.1 ± 0.7

2.1 ± 0.4

2.8 ± 1.1

RP1

0.28

0.598

Non-RP

(n = 17)

2.3 ± 1.1

2.5 ± 1.1

2.4 ± 1.2

2.2 ± 0.9

2.0 ± 0.8

1.7 ± 0.5

time

2.36

0.043

       

time*RP1

4.79

0.001

RP2

(n = 8)

2.5 ± 1.0

1.9 ± 0.6

1.8 ± 0.7

1.9 ± 0.6

2.1 ± 0.7

3.3 ± 1.7

RP2

0.05

0.828

Non-RP

2.6 ± 0.9

2.6 ± 0.9

2.3 ± 0.9

2.2 ± 0.8

2.0 ± 0.9

2.0 ± 0.9

time

3.24

0.008

(n = 26)

      

time*RP2

6.27

0.0001

  1. Abbreviations: RT, radiation therapy; wks, weeks; RP1, development of any grade of radiation pneumonitis; RP2, development of grade ≥ 2 radiation pneumonitis