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Table 1 Inhibitors of ATM and/or ATR

From: The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

Study

Inhibitor/Concentration

Reference

 

Caffeine

CGK733

KU55933

 

Hickson et al., 2004

-

-

0.03- 10 μM

[6]

Cowell et al., 2005

-

-

1-20 μM

[7]

Byrant and Helleday, 2006

-

-

2-20 μM

[21]

Nakai-Murakami et al., 2007

-

-

1 mM

[32]

Al-Minawi et al., 2008

2 mM

10 μM

-

[33]

Yamauchi et al., 2008

-

-

10 μM

[34]

Cruet-Hennequart et al., 2008

-

10 μM

10 μM

[10]

Goldstein et al., 2008

-

0.6 μM

-

[11]

Crescenzi et al., 2008

1-5 mM

10- 20 μM

20- 40 μM

[13]

Bhattacharya et al., 2008

-

20 μM

-

[9]

  1. Selected studies involving the exposure of mammalian cell lines to the ATM and/or ATR inhibitors caffeine, CGK733 and KU55933.
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Radiation Oncology

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