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Figure 2 | Radiation Oncology

Figure 2

From: Pharmacokinetics and biodistribution of Erufosine in nude mice - implications for combination with radiotherapy

Figure 2

Biodistribution of Erufosine after repeated drug injections. Mice were separated into 24 groups and treated every 48 hours with a intraperitoneal or subcutaneous injection of Erufosine at the indicated concentrations for one, two or three weeks. At the end of the treatment period mice were killed, organs removed and organ concentrations of Erufosine were determined by LC-MS/MS analysis. All values are means ± SD (n = 3-9). A. Organ concentrations of Erufosine after intraperitoneal treatment with 5, 10, 20 and 40 mg/kg body weight Erufosine for one (left panel), two (middle panel) or three weeks (right panel). B. Organ concentration of Erufosine after subcutaneous treatment with 5, 10, 20 and 40 mg/kg body weight Erufosine for one (left panel), two (middle panel) or three weeks (right panel). Three weeks subcutaneous treatment with 40 mg/kg body weight Erufosine is missing due to local toxicity.

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