Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking

Table 6 Comparison of acute and late GI and GU toxicity rates with the literature

Study	Pts	RT	Dose (Gy)	FU (months)	Tox	Acute GI grade 2/3	Late GI grade 2/3	Acute GU grade 2/3	Late GU grade 2/3	Ref
Skala et al.	690	3D/IMRT	≤ 79.8	37#	RTOG	n.a.	2.5%/0.7%	n.a.	8.8/0.9	22
Lips et al.	331	IMRT	76	47*	CTC/RTOG¹	30%/0	9%/1%	47%/3%²	21%/4%²	23
Current study	39	IMRT	80	29#	CTC	3%/0	8%/0	61%/3%	26%/3%

Abbreviations: GI = gastrointestinal; GU = genitourinary; Pts = patients; RT = radiotherapy; FU = follow-up; Tox = toxicity score used; Ref = reference; 3D = three-dimensional conformal radiation therapy; IMRT = intensity modulated radiation therapy; RTOG = Radiation Therapy Oncology Group toxicity criteria; n.a. = not applicable; CTC = Common Toxicity Criteria; # median (months); * mean (months); ¹ For acute toxicity CTC criteria were used and for late toxicity RTOG criteria. ² plus 0.3% of patients with grade 4 toxicity.

ISSN: 1748-717X