Study
|
Pts
|
RT
|
Dose (Gy)
|
FU (months)
|
Tox
|
Acute GI grade 2/3
|
Late GI grade 2/3
|
Acute GU grade 2/3
|
Late GU grade 2/3
|
Ref
|
---|
Skala et al.
|
690
|
3D/IMRT
|
≤ 79.8
|
37#
|
RTOG
|
n.a.
|
2.5%/0.7%
|
n.a.
|
8.8/0.9
|
22
|
Lips et al.
|
331
|
IMRT
|
76
|
47*
|
CTC/RTOG1
|
30%/0
|
9%/1%
|
47%/3%2
|
21%/4%2
|
23
|
Current study
|
39
|
IMRT
|
80
|
29#
|
CTC
|
3%/0
|
8%/0
|
61%/3%
|
26%/3%
| |
- Abbreviations: GI = gastrointestinal; GU = genitourinary; Pts = patients; RT = radiotherapy; FU = follow-up; Tox = toxicity score used; Ref = reference; 3D = three-dimensional conformal radiation therapy; IMRT = intensity modulated radiation therapy; RTOG = Radiation Therapy Oncology Group toxicity criteria; n.a. = not applicable; CTC = Common Toxicity Criteria; # median (months); * mean (months); 1 For acute toxicity CTC criteria were used and for late toxicity RTOG criteria. 2 plus 0.3% of patients with grade 4 toxicity.