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Table 5 Trials of WBRT plus radiation sensitizers for brain metastases

From: Neuropsychological testing and biomarkers in the management of brain metastases

Study (ref) Year n Radioenhancer (Gy)/number of fractions Median Survival (months) WBRT + RS vs WBRT
Eyre et al. [31] 1984 111 metronidazole 30/10 3.0 vs 3.5
DeAngelis et al. [32] 1989 58 lonidamine 30/10 3.9 vs 5.4
Komarnicky et al. [33] 1991 779 misonidazole 30/6-10 3.9
Phillips et al. [34] 1995 72 BUdR 37.5/15 4.3 vs 6.1
Mehta et al. [35] 2003 401 motexafin gadolinium 30/20 5.2 vs 4.9
Shaw et al. [30] 2003 57 efaproxiral 30/10 7.3 vs 3.4
Suh et al. [36] 2006 515 efaproxiral 30/10 5.4 vs 4.4
Knisely et al. [37] 2008 183 thalidomide 37.5/15 3.9 vs 3.9
  1. Abbreviations: RS = Radiation Sensitizer, BUdR = bromodeoxyuridine