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Table 1 RTOG RPA classification for brain metastases and associated survival by class in patients treated with WBRT

From: Neuropsychological testing and biomarkers in the management of brain metastases

Class

Patient characteristics

Median survival (months)

I

KPS ≥ 70

7.1

 

Age < 65 years

 
 

Controlled primary tumor

 
 

No extracranial metastases

 

II

KPS ≥ 70

4.2

 

One of the following:

 
 

   Age ≥ 65

 
 

   Uncontrolled or synchronous primary disease

 
 

   Extracranial metastases

 

III

KPS < 70

2.3

  1. Abbreviations: RTOG = Radiation Therapy Oncology Group; RPA = recursive partitioning analysis; KPS = Karnofsky performance status.