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Table 1 Clonogenic survival and γH2AX retention for SiHa cells after acute or protracted exposures

From: Effect of prolonging radiation delivery time on retention of gammaH2AX

Dose

Integral Exposure Time (min)

Surviving Fractiona (number of samples)

Residual γH2AXb (number of samples)

2 Gy acute

0.5

0.446 ± 0.013 (12)

1.265 ± 0.089 (12)

2 Gy protracted

30 and 60

0.478 ± 0.018 (18)*

1.218 ± 0.087 (18)

4 Gy acute

1

0.164 ± 0.014 (18)

1.461 ± 0.142 (12)

4 Gy protracted

30 and 60

0.199 ± 0.012 (24)*

1.387 ± 0.128 (18)

  1. a Mean and standard deviation for clonogenic surviving fraction expressed relative to the unirradiated control cells. Cells were plated for survival 24 h after irradiation.
  2. * Result significantly different relative to the response of cells exposed in ≤ 1 min.
  3. b Mean and standard deviation for γH2AX expression measured 24 h after irradiation and expressed relative to the unirradiated cells.