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Table 1 Study flow chart.

From: Study protocol of the German "Registry for the Detection of Late Sequelae after Radiotherapy in Childhood and Adolescence" (RiSK)

Timepoint Documentation Special needs
Treatment planning and radiotherapy Basic data (see documentation form part 1)  
  Organ doses (see documentation form part 2) 1. Dose-volume-histogram for lungs, heard, liver and kidneys, if in radiation field. Therefore CT-based treatment planning is mandatory if irradiation is performed to the thorax or abdomen.
   2. Dosimetry of the thyroid gland if irradiation in head/neck area or mediastinum
   3. Dosimetry of the testes if irradiation is performed to the abdomen or to the upper part of the lower extremity
6–8 weeks after end of radiotherapy
Follow-up examination
Documentation of maximal side effects that occured during or few weeks after radiotherapy according RTOG/EORTC criteria (see documentation form) Only clinical examination
1 year after end of radiotherapy: follow-up examination Evaluation of late sequelae according to RTOG/EORTC criteria (see documentation form) Only clinical examination, blood values to be asked from paediatricians
2nd-10th (if feasible) year after radiotherapy follow-up examination 1×/year Evaluation of late sequelae according to RTOG/EORTC criteria (see documentation form) Only clinical examination, blood values to be asked from paediatricians
  1. The documentation forms have to be sent to the RiSK study trial center in Münster: RiSK-Study trial centre, Department of Radiotherapy, University Hospital of Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany, Phone: +49-251-83-47384, Fax: +49-251-83-47355, E-Mail:radtox@uni-muenster.de