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Table 4 Mean percent volume of OAR receiving various dose levels for N2-3 and/or T4 patients (upper limit of fields at L5-S1) for a 59.4 Gy treatment

From: Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans

  

Mean volume receiving above threshold dose (%)†

Organ

Threshold dose (Gy)

A

B

C

D

Bladder

30

100

88.6* (76–100)

84.9* (71–99)

77.0* (68–84)

 

40

100

60.2* (43–74)

52.5* (39–70)

39.0* (30–54)

Genitalia/perineum

30

87.0 (60–100)

64.4 (26–93)

46.2* (26–68)

32.8* (20–53)

 

40

85.1 (56–99)

25.9* (2–43)

9.8* (1–26)

7.4* (0–26)

Small bowel

30

64.4 (48–89)

43.6* (38–52)

43.0* (37–50)

45.8 (39–55)

 

40

62.1 (45–87)

26.5* (21–30)

25.8* (19–30)

28.3* (20–35)

Iliac crests

10

59.9 (57–63)

52.2* (45–57)

51.4* (45–56)

56.0 (47–60)

 

20

50.2 (47–54)

33.0* (30–37)

32.8* (30–37)

34.3* (30–38)

Femoral heads

45

29.9 (21–39)

15.7* (8–21)

8.8* (6–14)

14.6* (11–17)

  1. †Mean in % (range).
  2. * denotes statistically significant p values (p < 0.05) as compared with arm A.