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Table 3 Mean percent volume of OAR receiving various dose levels for N0–N1 patients (upper limit of fields at S2–S3) for a 59.4 Gy treatment

From: Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans

  

Mean volume receiving above threshold dose (%) †

Organ

Threshold dose (Gy)

A

B

C

D

Bladder

30

100

87.8* (80–95)

86.7* (78–92)

80.8* (74–83)

 

40

100

65.2* (55–76)

57.4* (43–69)

46.2* (35–55)

Genitalia/perineum

30

85.8 (72–99)

47.6* (23–88)

36.4* (23–52)

26.6* (13–44)

 

40

80.4 (65–98)

20.2* (0–54)

7.2* (0.2–18)

2.7* (0–7)

Small bowel

30

59.3 (37–72)

40.1* (28–49)

39.6* (28–48)

39.7 (29–45)

 

40

56.1 (35–68)

25.0* (17–31)

24.5* (16–30)

26.7* (19–30)

Iliac crests

10

39.8 (33–52)

37.4 (33–44)

37.1 (33–44)

39.6 (35–47)

 

20

33.7 (28–47)

28.4 (26–30)

28.2 (26–30)

28.3 (27–30)

Femoral heads

45

33.8 (25–51)

23.3 (8–45)

14.6* (2–30)

20.9* (12–30)

  1. †Mean in % (range).
  2. * denotes statistically significant p values (p < 0.05) as compared with arm A.