| |
pre-RT
|
6 weeks
|
6 mo
|
12 mo
|
5 years
|
Significance
|
|---|
|
EORTC QLQ-C30(+3)
| | | | | | |
|
Functioning scales*
| | | | | | |
|
Cognitive
|
90.1
|
88.0
|
88.6
|
90.2
|
87.3
|
NS
|
|
Emotional
|
75.8
|
83.5
|
83.2
|
85.5
|
83.7
|
NS
|
|
Physical
|
80.6
|
85.0
|
85.0
|
87.0
|
85.1
|
NS
|
|
Role
|
75.8
|
83.5
|
83.2
|
85.5
|
83.7
|
NS
|
|
Social
|
86.9
|
88.8
|
89.4
|
93.6
|
87.8
|
NS
|
|
Global QOL*
|
71.6
|
73.3
|
80.1
|
81.6
|
80.6
|
NS
|
|
Symptom scales†
| | | | | | |
|
Fatique
|
24.3
|
30.5
|
26.8
|
23.4
|
27.5
|
p < 0.01
|
|
Pain
|
14.3
|
11.6
|
15.0
|
8.6
|
12.0
|
NS
|
|
Nausea and vomiting
|
3.6
|
7.4
|
1.2
|
2.2
|
0.8
|
p < 0.01
|
|
Single items†
| | | | | | |
|
Dyspnoea
|
16.7
|
13.2
|
18.7
|
15.4
|
14.3
|
NS
|
|
Insomnia
|
24.6
|
25.6
|
21.1
|
17.0
|
15.5
|
p < 0.01
|
|
Appetite loss
|
7.9
|
14.0
|
8.9
|
7.7
|
10.1
|
p < 0.05
|
|
Constipation
|
3.2
|
10.1
|
5.7
|
7.7
|
7.0
|
NS
|
|
Diarrhoea
|
1.6
|
2.3
|
1.6
|
6.0
|
0.0
|
NS
|
|
Financial problems
|
5.6
|
5.4
|
4.1
|
5.1
|
5.7
|
NS
|
|
EORTC QLQ-H&N35
| | | | | | |
|
Symptom scales-single items†
| | | | | | |
|
Pain
|
10.6
|
19.4
|
19.1
|
15.5
|
9.5
|
p < 0.01
|
|
Swallowing
|
9.8
|
20.5
|
18.2
|
11.4
|
9.9
|
p < 0.01
|
|
Senses (taste/smell)
|
5.6
|
23.3
|
17.1
|
12.0
|
12.3
|
p < 0.01
|
|
Speech
|
23.8
|
17.8
|
15.0
|
11.5
|
14.4
|
p < 0.01
|
|
Social eating
|
7.9
|
19.8
|
14.8
|
10.7
|
10.6
|
p < 0.01
|
|
Social contact
|
4.0
|
6.2
|
2.6
|
3.8
|
4.6
|
NS
|
|
Sexuality
|
14.8
|
78.7
|
17.1
|
20.7
|
25.4
|
NS
|
|
Teeth
|
10.5
|
31.8
|
21.1
|
19.8
|
18.7
|
NS
|
|
Open mouth (trismus)
|
11.1
|
14.0
|
15.5
|
9.4
|
13.9
|
NS
|
|
Dry mouth
|
11.9
|
48.8
|
50.4
|
47.0
|
41.1
|
p = 0.01
|
|
Sticky saliva
|
14.6
|
46.5
|
40.7
|
35.0
|
24.6
|
p < 0.01
|
|
Cough
|
17.5
|
23.3
|
26.0
|
18.8
|
13.5
|
p < 0.01
|
|
Nutrition supplements
|
7.3
|
32.6
|
12.2
|
12.8
|
4.9
|
p < 0.01
|
- *Higher score indicates better function. † Higher score indicates more symptoms. ‡ Significance based on ordinal regression model using non-transformed data. QLQ, quality of life; RT, radiotherapy; NS, not significant.
