Table 1 Trials of radiotherapy following local excision for DCIS

Characteristic

Date

1985–1990

1986–1996

1990–1998

1987–1999

Patients Randomised

818

1010

1030

1046

Median follow-up

12 YEARS

4 YEARS

4.3 YEARS

5.2 YEARS

Symptomatic

19%

28%

NA

12.9%

Central path review

76%

85%

79%

20%

Dose

50 Gy/25 Fraction

50 Gy/25 Fractions

50 Gy/25 Fractions

50 – 54 Gy/25–27 fractions

Quality by Jadad

4

4

4

4

Population

Pre- and post-menopausal Pts. All pts had tumour free margins after BCT. Women with localized ductal carcinoma in situ detected by physical examination or mammography were eligible, both ductal carcinoma in situ and lobular carcinoma in situ were also eligible.

RT 411 pts

BCT403 pts

DCIS<5 cm 1 002/1 010 pts analysed Extent of free margins was not specified, evidence of invasive carcinoma or Paget's disease of the nipple, were ineligible for the study.

RT 502 pts

BCT 500 pts

Screening detected tumor, complete excision of the carcinoma, free margins. typical ductal hiperplasia excluded. Excluded patients with lobular carcinoma in situ or atypical ductal hyperplasia in the absence of ductal carcinoma in situ, those in whom pathological margins of disease were uncertain, and people with Paget's disease of the nipple.

RT 267

BCT 544

Pathology margins clear, DCIS grade I and II B/2 mm were classified as atypical ductal hyperplasia Exclusion criteria were Paget's disease of the nipple, invasive carcinoma or intracystic carcinoma in situ, ongoing pregnancy or a history of previous or concurrent malignancy

RT 534

BCT 533