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Table 2 Table 2

From: Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence

Exon/Variant Genotype Level of adverse effects P-value
   0 1 2 3  
a)       
Pleural thickening
Exon 20 GG 136 82 23 1 0.001
IVS20+28delG GA 4 2 0 1  
Exon 31, rs1800058 CC 135 82 23 1 > 0.001
4258 C>T CT 5 1 0 1  
Leu > Phe       
Exon 41, rs3092910       
5793 T>C TT 136 82 23 1 0.001
Ala > Ala TC 4 2 0 1  
Lung fibrosis
Exon 31, rs1800058 CC 66 156 18 1 > 0.001
4258 C>T CT 3 3 0 1  
Leu > Phe       
Development of telangiectasias
Exon 39, rs1801516 GG 35 33 41 70 0.042
5557 G>A GA 11 14 10 20  
Asp > Asn AA 4 1 0 0  
Atrophy
Exon 31, rs1800058       
4258 C>T CC 35 57 74 65 0.02
Leu > Phe CT 4 1 0 2  
b)       
Pleural thickening
Exon 20 GG 69 61 19 0 > 0.001
IVS20+28delG GA 2 2 0 1  
Exon 41, rs3092910 TT 69 61 19 0 > 0.001
5793 T>C TC 2 2 0 1  
Ala > Ala       
Lung fibrosis
Exon 32, rs1800889 CC 11 111 13 0 0.009
4578 C>T CT 4 11 2 1  
Pro > Pro       
Development of telangiectasias
Exon 39, rs1801516 GG 14 21 28 47 0.027
5557 G>A GA 4 9 9 15  
Asp > Asn AA 3 1 0 0  
c)       
Costal fractures
Exon 9, rs3218674 CC 75 12 1 0 0.043
735 C>T CT 6 0 1 0  
Val > Val       
Pleural thickening
Exon 31, rs1800058 CC 64 20 4 0 0.001
4258 C>T CT 5 0 0 1  
Leu > Phe       
Lung fibrosis
Exon 31, rs1800058 CC 51 35 2 0 0.002
4258 C>T CT 3 2 0 1  
Leu > Phe       
Subcutaneous fibrosis
Exon 32, rs1800889 CC 32 25 16 5 0.022
4578 C>T CT 6 1 0 3  
Pro > Pro       
  1. Associations of genetic variance in the ATM gene with radiation induced side effects in the Norwegian breast cancer patients: for all patients combined (a), treatment A (4.3 Gy *10, b) and treatment B (2.5 Gy *25, c) (organized by adverse effect, level of adverse effect is divided into four groups: none (0), little (1), some (2) and substantial (3)). (The P-values are not adjusted for multiple testing)