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Table 1 Median doses to the left anterior descending coronary artery (LAD) in [Gy] for 3 differently sized target volumes

From: Influence of different treatment techniques on radiation dose to the LAD coronary artery

 

Maximum dose (range)*

Median dose (range)

Median volume receiving 100%

Median volume receiving 25%*

Small, AP-PA

28.5 Gy (27.3–29.4)

23.4 Gy (18.3–27.0)

0% (0-0)

69% (65–80)

Small, 4-field

29.7 Gy (28.5–30.0)

21.3 Gy (13.2–26.1)

0% (0-0)

72% (56–80)

Small, IMRT

28.5 Gy (21.3–29.7)

11.1 Gy (8.7–14.1)

0% (0-0)

70% (53–75)

Intermediate, AP-PA

30.6 Gy (30.0–31.2)

30.0 Gy (26.4–30.0)

50% (1–82)

98% (74–100)

Intermediate, 4-field

30.6 Gy (30.0–30.9)

29.0 Gy (19.2–30.3)

23% (0–93)

100% (89–100)

Intermediate, IMRT

26.9 Gy (23.7–30.0)

15.9 Gy (10.8–29.4)

0.25% (0–26)

92% (78–100)

Large, AP-PA

31.5 Gy (29.7–31.8)

30.5 Gy (30.2–30.6)

90% (60–98)

100% (100-100)

Large, 4-field

31.2 Gy (30.6–31.8)

28.5 Gy (21.9–29.4)

23% (18–25)

100% (100-100)

Large, IMRT

29.1 Gy (27.3–31.2)

15.9 Gy (15.0–21.9)

3% (0–9)

88% (82–95)

  1. * Statistical testing was not performed for these parameters.
  2. p < 0.01 for comparison of the median LAD dose with ap-pa vs. IMRT and 4-field vs. IMRT.
  3. p < 0.01 for comparison of the median volume receiving 100% with ap-pa vs. both 4-field and IMRT (for both intermediate and large PTV). The differences between 4-field and IMRT are also statistically significant.
  4. Small volume: upper mediastinal plus paraclavicular nodal areas (566–860 ccm), intermediate volume: lower mediastinal nodes in addition (774–1337 ccm), large volume: hilar nodes in addition (936–1664 ccm)