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Table 1 Median doses to the left anterior descending coronary artery (LAD) in [Gy] for 3 differently sized target volumes

From: Influence of different treatment techniques on radiation dose to the LAD coronary artery

  Maximum dose (range)* Median dose (range) Median volume receiving 100% Median volume receiving 25%*
Small, AP-PA 28.5 Gy (27.3–29.4) 23.4 Gy (18.3–27.0) 0% (0-0) 69% (65–80)
Small, 4-field 29.7 Gy (28.5–30.0) 21.3 Gy (13.2–26.1) 0% (0-0) 72% (56–80)
Small, IMRT 28.5 Gy (21.3–29.7) 11.1 Gy (8.7–14.1) 0% (0-0) 70% (53–75)
Intermediate, AP-PA 30.6 Gy (30.0–31.2) 30.0 Gy (26.4–30.0) 50% (1–82) 98% (74–100)
Intermediate, 4-field 30.6 Gy (30.0–30.9) 29.0 Gy (19.2–30.3) 23% (0–93) 100% (89–100)
Intermediate, IMRT 26.9 Gy (23.7–30.0) 15.9 Gy (10.8–29.4) 0.25% (0–26) 92% (78–100)
Large, AP-PA 31.5 Gy (29.7–31.8) 30.5 Gy (30.2–30.6) 90% (60–98) 100% (100-100)
Large, 4-field 31.2 Gy (30.6–31.8) 28.5 Gy (21.9–29.4) 23% (18–25) 100% (100-100)
Large, IMRT 29.1 Gy (27.3–31.2) 15.9 Gy (15.0–21.9) 3% (0–9) 88% (82–95)
  1. * Statistical testing was not performed for these parameters.
  2. p < 0.01 for comparison of the median LAD dose with ap-pa vs. IMRT and 4-field vs. IMRT.
  3. p < 0.01 for comparison of the median volume receiving 100% with ap-pa vs. both 4-field and IMRT (for both intermediate and large PTV). The differences between 4-field and IMRT are also statistically significant.
  4. Small volume: upper mediastinal plus paraclavicular nodal areas (566–860 ccm), intermediate volume: lower mediastinal nodes in addition (774–1337 ccm), large volume: hilar nodes in addition (936–1664 ccm)