Table 1 Overview on the available mechanistic data regarding the activity of coxibes in prostate cancer
Cancer Type | Treatment | Investigation | Results | Reference |
|---|---|---|---|---|
LNCaP PC 3 | Celecoxib | In vitro | Increased cell death/apoptosis | Kamijo 2001 |
PC 3 | Celecoxib | In vitro/Xenograft | G1 block/reduced DNA synthesis/growth inhibition by COX-2 independent mechanism | Patel 1999 |
LNCaP PC 3 | Celecoxib | In vitro | Growth inhibition | Srinath 2003 |
LNCaP PC 3 | Celecoxib | In vitro | Induction of apoptosis by blocking Akt activation independently of Bcl-2 | Hsu 2000 |
PC 3 | Celecoxib+ radiation | In vitro | Up-regulation of COX-2, elevated PGE2 levels after irradiation | Steinauer 2000 |
LNCaP PC3 DU-145 | Celecoxib+ radiation | In vitro | Bax-independent pro-apoptotic effect of Celecoxib | Handrick 2004 |
LNCaP DU-145 PC-3ML | Celecoxib+ COL-3/Docetaxel | In vitro/Xenograft | Augmentation of chemotherapeutic drug-induced apoptosis by activation of caspase 3 and 9 | Dandekar 2005 |