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Table 4 Characteristics on patients with grade 3/4 late term effects (19 events in 18 patients). In all cases with grade 3/4 ulcers not healing during a 6 months period (n = 3, grey bars), ulcer persistence was found basing on tumor persistence (No 3,13, 16; data from these patient as well as of the 2 individuals with grade 3 xerostomia were excluded from this volumetric analysis (EA) of the 14 patients with grade 3/4 lesions).

From: IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients

         Outcome
No. Dg TNM Sequence Grade 3/4 t post RT (m) Duration (m) Treatment NTR Tumor PTD d/f SIB Dmax G3/4 GTV PT (cc) PTV1 (cc) cc>110% D
1 Cent oro T3N2c Prim Ulcer 4 7 - Healed ANED 66/54 2.2 75.7 56 213 0
2 Supragl T2N2b Prim Ulcer 6 1 - Healed ANED 69.6/54 2.11 75.9 20.8 162.5 0
3 Oral cav T2N0 Postop Ulcer 3 4 0 Healed ANED 66/54 2 80.7 14 81.7 1.6
4 Hypo T4N1 Prim Ulcer 3 3 HBO Healed ANED 66/54 2.2 75.8 74 299 0
5 " " " Larynx fibrosis 10 Persistent (30) Tracheostoma Tracheostoma ANED " 2.2 75.8 " " 0
6 Hypo T2N2b Prim Ulcer 4 5 - Healed ANED 69.6/54 2.11 74.8 27 145 0
7 Cent oro T3N2b Prim Ulcer 6 1 - Healed ANED 66/54 2.2 77.3 30 201 2
8 Hypo T2N2b Prim Ulcer 6 2 - Healed ANED 69.6/54 2.11 76.8 34.5 220 2.2
9 Cent oro T3N0 Prim Ulcer 4 3 HBO Healed ANED 66/54 2.2 77.3 29 77.7 7.7
10 Lat oro T3N2b Postop Ulcer 2 3 - Healed ANED 65.4/54 2.11 72.8 7.8 212 0
11 Cent oro T3N2b Prim Bone 4 6 Surgery Healed ANED 66/54 2.2 76.5 37.5 208 2
12 Hypo T3N0 Prim Dysphagia 2 ? (8) Dilatation Persistent ANED 69.6/54 2.11 75.7 32 149.5 0
13 Hypo T3N2c Prim Dysphagia 5 Persistent (14) Dilatation Persistent ANED 68.2/54 2.2 79.2 21.5 210 2.1
14 Cent oro T3N2b Prim Dysphagia 5 ? (9, lost) - ? ANED 69.6/54 2.11 76.7 24 113 0
15 Oral cav T2N2c Prim Ulcer 3 Persistent - Persistent TU Persistent 69.6/54 2.11 EA EA EA EA
16 Lat oro T2N1 Prim Ulcer 2 Persistent - Persistent TU Persistent 69.6/54 2.11 EA EA EA EA
17 Cent oro T3N2b Prim Bleeding ulcer 0 Persistent Surgery Persistent TU Persistent 69.6/54 2.11 EA EA EA EA
18 Hypo T4N2a Prim Xerostomia 0 Persistent (14) - Persistent ANED 69.6/54 2.11 EA EA EA EA
19 Cent oro T1N2b postop Xerostomia 0 Persistent (12) - Persistent ANED 64/54 2 EA EA EA EA
Mean      3.6 3.2       76.5 31.4 176.3 1.3
Range      0–10 1–7      2.0–2.20 72.8–80.7 2.5–37.5 78–299 0–7.7
  1. t postRT time (in months) from IMRT completion to appearance of late term reaction
  2. NTR normal tissue reaction
  3. PTD prescribed total dose