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Table 2 Comparison of different radiation therapy fractionations according to Abratt model.

From: Absence of toxicity with hypofractionated 3-dimensional radiation therapy for inoperable, early stage non-small cell lung cancer

  Dose per fraction No of fractions Time (days) Total Dose (Gy) ID2 acute reaction TED ID2 late reaction
McGill 3.5 Gy 15 19 52.5 59 59 68
Standard 2 Gy 2 Gy 39 53 78 78 59 78
Sunnybrook13 4 Gy 12 16 48 56 56 67
Wales14 2.75 20 26 55 58 55 60
  1. ID2 = isoeffective dose at 2 Gy per fraction; acute reaction α/β = 10; late reaction α/β = 3. TED = tumor effect dose (used to indicate the ID2 modified for overall treatment time to account for repopulation) (5).
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