Table 1 Drug toxicity enhancement factors (EF's) obtained in human tumour cell lines when cells were blocked in G2 with irradiation and then subjected to Pentoxifylline and a TC: 05 dose of a cytotoxic drug. Data adapted from [6]

4197

p53 wt ^b

D, M, CP

1.3

3.0

2.6

4451

p53 mut ^b

D, M, CP

2.3

8.6

52

Be11

p53 wt^b

D, M, CP

1.4

2.3

1.2

MeWo

p53 mut ^b

D, M, CP

2.8

85

74

DU 145

p53 mut ^c

V, E, CP

4.8

1.5

4.1

BM1604

p53 mut ^c

V, E, CP

2.6

1.0

4.5

LNCaP

p53 wt ^c

V, E, CP

1.4

1.5

1.6