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  1. Research

    Lung metastases treated with stereotactic body radiotherapy: the RSSearch® patient Registry’s experience

    To report overall survival and local control for patients identified in the RSSearch® Patient Registry with metastatic cancer to the lung treated with SBRT.

    Anthony Ricco, Joanne Davis, William Rate, Jun Yang, David Perry, John Pablo, David D‘Ambrosio, Sanjeev Sharma, Srinath Sundararaman, James Kolker, Kimberly M. Creach and Rachelle Lanciano

    Radiation Oncology 2017 12:35

    Published on: 1 February 2017

  2. Research

    Is pulmonary artery a dose-limiting organ at risk in non-small cell lung cancer patients treated with definitive radiotherapy?

    Our previous study suggested that some pulmonary artery (PA) dosimetric parameters were associated with mortality in unresectable non-small cell lung cancer (NSCLC) treated with definitive radiotherapy. The pr...

    Jie-Tao Ma, Li Sun, Xin Sun, Zhi-Cheng Xiong, Yang Liu, Shu-Ling Zhang, Le-Tian Huang and Cheng-Bo Han

    Radiation Oncology 2017 12:34

    Published on: 1 February 2017

  3. Research

    Fully automated treatment planning of spinal metastases – A comparison to manual planning of Volumetric Modulated Arc Therapy for conventionally fractionated irradiation

    Planning for Volumetric Modulated Arc Therapy (VMAT) may be time consuming and its use is limited by available staff resources. Automated multicriterial treatment planning can eliminate this bottleneck. We com...

    Daniel Buergy, Abdul Wahab M. Sharfo, Ben J. M. Heijmen, Peter W. J. Voet, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr and Florian Stieler

    Radiation Oncology 2017 12:33

    Published on: 31 January 2017

  4. Research

    Helical tomotherapy of spinal chordomas: French Multicentric, retrospective study of a cohort of 30 cases

    To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible.

    Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo and Guy Kantor

    Radiation Oncology 2017 12:32

    Published on: 31 January 2017

  5. Research

    Helical TomoTherapy for locally advanced or recurrent breast cancer

    We report our experience of using helical tomotherapy (HT) to treat large and irregular shaped loco-regional advanced breast cancer target volumes embracing various organs at risk.

    M. N. Duma, C. Heinrich, C. Schönknecht, B. Chizzali, M. Mayinger, M. Devecka, S. Kampfer and S. E. Combs

    Radiation Oncology 2017 12:31

    Published on: 28 January 2017

  6. Short report

    Short report: interim safety results for a phase II trial measuring the integration of stereotactic ablative radiotherapy (SABR) plus surgery for early stage non-small cell lung cancer (MISSILE-NSCLC)

    A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We rep...

    David A. Palma, Timothy K. Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V. Louie, Eric Frechette, George B. Rodrigues, Brian Yaremko, Edward Yu, A. Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner…

    Radiation Oncology 2017 12:30

    Published on: 27 January 2017

  7. Review

    Present state and issues in IORT Physics

    Literature was reviewed to assess the physical aspects governing the present and emerging technologies used in intraoperative radiation therapy (IORT). Three major technologies were identified: treatment with ...

    Frank W. Hensley

    Radiation Oncology 2017 12:37

    Published on: 27 January 2017

  8. Review

    A review of substitute CT generation for MRI-only radiation therapy

    Radiotherapy based on magnetic resonance imaging as the sole modality (MRI-only RT) is an area of growing scientific interest due to the increasing use of MRI for both target and normal tissue delineation and ...

    Jens M. Edmund and Tufve Nyholm

    Radiation Oncology 2017 12:28

    Published on: 26 January 2017

  9. Review

    Current controversies in radiotherapy for breast cancer

    Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative an...

    David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D. Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz and Rolf Sauer

    Radiation Oncology 2017 12:25

    Published on: 23 January 2017

  10. Research

    Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

    Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Radiation Oncology 2017 12:26

    Published on: 23 January 2017

  11. Review

    Intraoperative radiotherapy (IORT) as boost in breast cancer

    The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT precedin...

    Felix Sedlmayer, Roland Reitsamer, Frederik Wenz, Elena Sperk, Christoph Fussl, Julia Kaiser, Ingrid Ziegler, Franz Zehentmayr, Heinz Deutschmann, Peter Kopp and Gerd Fastner

    Radiation Oncology 2017 12:23

    Published on: 19 January 2017

  12. Review

    Intraoperative radiation therapy (IORT) in pancreatic cancer

    Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy re...

    Robert Krempien and Falk Roeder

    Radiation Oncology 2017 12:8

    Published on: 19 January 2017

  13. Review

    Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

    Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in ...

    Marco Krengli, Carla Pisani, Letizia Deantonio, Daniela Surico, Alessandro Volpe, Nicola Surico and Carlo Terrone

    Radiation Oncology 2017 12:18

    Published on: 19 January 2017

  14. Review

    Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

    Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectivenes...

    Carsten Herskind, Lin Ma, Qi Liu, Bo Zhang, Frank Schneider, Marlon R. Veldwijk and Frederik Wenz

    Radiation Oncology 2017 12:24

    Published on: 19 January 2017

  15. Review

    Intraoperative radiation therapy (IORT) in soft-tissue sarcoma

    Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the...

    Falk Roeder and Robert Krempien

    Radiation Oncology 2017 12:20

    Published on: 19 January 2017

  16. Research

    Elective breast radiotherapy including level I and II lymph nodes: A planning study with the humeral head as planning risk volume

    The aim of this study was to assess the dose to the humeral head planning risk volume with the currently used high tangential fields (HTF) and compare different planning techniques for breast radiotherapy incl...

    Kathrin Surmann, Jorien van der Leer, Tammy Branje, Maurice van der Sangen, Maarten van Lieshout and Coen W. Hurkmans

    Radiation Oncology 2017 12:22

    Published on: 18 January 2017

  17. Research

    Cell-in-cell structures are more potent predictors of outcome than senescence or apoptosis in head and neck squamous cell carcinomas

    This study sheds light on cell inactivating processes with focus on the phenomenon of cell-in-cell (CIC). Cell-in-cell describes a cell process where one cell is being engulfed by another non-professional phag...

    Hannah Schenker, Maike Büttner-Herold, Rainer Fietkau and Luitpold V. Distel

    Radiation Oncology 2017 12:21

    Published on: 18 January 2017

  18. Research

    The use of dose-escalated radiation for locally advanced non-small cell lung cancer in the U.S., 2004–2013

    The clinical effects of radiation dose-intensification in locally advanced non-small cell lung (NSCLCa) and other cancers are challenging to predict and are ideally studied in randomized trials. The purpose of...

    John P. Christodouleas, Matthew D. Hall, Marjorie A. van der Pas, Wensheng Guo, Timothy E. Schultheiss and Peter Gabriel

    Radiation Oncology 2017 12:19

    Published on: 17 January 2017

  19. Research

    Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs

    The purpose of this study was to determine the distribution of 4-borono-2-18F-fluoro-phenylalanine (18F-BPA) and L-[methyl-11C] methionine (11C-Met) in normal organs and tumors and to evaluate the usefulness of 1...

    Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai and Kazuro Sugimura

    Radiation Oncology 2017 12:17

    Published on: 14 January 2017

  20. Research

    Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer

    In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could pr...

    Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Haruna Nishimaki and Shinobu Masuda

    Radiation Oncology 2017 12:16

    Published on: 13 January 2017

  21. Research

    Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer

    Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...

    Matthew J. Boyer, Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu and W. Robert Lee

    Radiation Oncology 2017 12:14

    Published on: 13 January 2017

  22. Research

    A comparative analysis between sequential boost and integrated boost intensity-modulated radiation therapy with concurrent chemotherapy for locally-advanced head and neck cancer

    Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-rela...

    Gregory Vlacich, Mark J. Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr and Anthony J. Cmelak

    Radiation Oncology 2017 12:13

    Published on: 13 January 2017

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