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  1. Research

    Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs

    The purpose of this study was to determine the distribution of 4-borono-2-18F-fluoro-phenylalanine (18F-BPA) and L-[methyl-11C] methionine (11C-Met) in normal organs and tumors and to evaluate the usefulness of 1...

    Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai and Kazuro Sugimura

    Radiation Oncology 2017 12:17

    Published on: 14 January 2017

  2. Research

    Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer

    In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could pr...

    Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Haruna Nishimaki and Shinobu Masuda

    Radiation Oncology 2017 12:16

    Published on: 13 January 2017

  3. Research

    A comparative analysis between sequential boost and integrated boost intensity-modulated radiation therapy with concurrent chemotherapy for locally-advanced head and neck cancer

    Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-rela...

    Gregory Vlacich, Mark J. Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr and Anthony J. Cmelak

    Radiation Oncology 2017 12:13

    Published on: 13 January 2017

  4. Research

    External beam radiotherapy for unresectable hepatocellular carcinoma, an international multicenter phase I trial, SAKK 77/07 and SASL 26

    To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC).

    Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour and Daniel M. Aebersold

    Radiation Oncology 2017 12:12

    Published on: 13 January 2017

  5. Research

    Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer

    Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...

    Matthew J. Boyer, Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu and W. Robert Lee

    Radiation Oncology 2017 12:14

    Published on: 13 January 2017

  6. Research

    Treatment planning comparison of IMPT, VMAT and 4π radiotherapy for prostate cases

    Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy...

    Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen and Ke Sheng

    Radiation Oncology 2017 12:10

    Published on: 11 January 2017

  7. Study protocol

    Dose escalation of Stereotactic Body Radiotherapy (SBRT) for locally advanced unresectable pancreatic cancer patients with CyberKnife: protocol of a phase I study

    Dose escalation of SBRT for locally advanced pancreatic cancer patients had been reported in several studies in one or three fractions, and phase I protocol was developed to investigate the maximum tolerated d...

    Shui-Wang Qing, Xiao-Ping Ju, Yang-Sen Cao and Huo-Jun Zhang

    Radiation Oncology 2017 12:6

    Published on: 9 January 2017

  8. Research

    Classifying high-risk versus very high-risk prostate cancer: is it relevant to outcomes of conformal radiotherapy and androgen deprivation?

    To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT).

    Akram Saad, Jeffrey Goldstein, Yaacov R. Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss and Zvi Symon

    Radiation Oncology 2017 12:5

    Published on: 6 January 2017

  9. Research

    The predictive value of 18F-FDG PET-CT for assessing the clinical outcomes in locally advanced NSCLC patients after a new induction treatment: low-dose fractionated radiotherapy with concurrent chemotherapy

    Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemothe...

    Maria Vittoria Mattoli, Mariangela Massaccesi, Alessandra Castelluccia, Valentina Scolozzi, Giovanna Mantini and Maria Lucia Calcagni

    Radiation Oncology 2017 12:4

    Published on: 5 January 2017

  10. Research

    Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system

    To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system.

    Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa and Hiroki Shirato

    Radiation Oncology 2017 12:3

    Published on: 5 January 2017

  11. Review

    Current status and perspectives of interventional clinical trials for glioblastoma – analysis of

    The records of 208.777 (100%) clinical trials registered at were downloaded on the 19th of February 2016. Phase II and III trials including patients with glioblastoma were selected for furth...

    Nikola Cihoric, Alexandros Tsikkinis, Giuseppe Minniti, Frank J Lagerwaard, Ulrich Herrlinger, Etienne Mathier, Ivan Soldatovic, Branislav Jeremic, Pirus Ghadjar, Olgun Elicin, Kristina Lössl, Daniel M Aebersold, Claus Belka, Evelyn Herrmann and Maximilian Niyazi

    Radiation Oncology 2017 12:1

    Published on: 3 January 2017

  12. Short report

    Beam Output Audit results within the EORTC Radiation Oncology Group network

    Beam Output Auditing (BOA) is one key process of the EORTC radiation therapy quality assurance program. Here the results obtained between 2005 and 2014 are presented and compared to previous results.

    Coen W. Hurkmans, Melissa Christiaens, Sandra Collette and Damien Charles Weber

    Radiation Oncology 2016 11:160

    Published on: 15 December 2016

  13. Research

    Three-dimensional surface and ultrasound imaging for daily IGRT of prostate cancer

    Image guided radiotherapy (IGRT) is an essential pre-requisite for delivering high precision radiotherapy. We compared daily variation detected by two non-ionizing imaging modalities (surface imaging and trans...

    Marco Krengli, Gianfranco Loi, Carla Pisani, Debora Beldì, Giuseppina Apicella, Valentina Amisano and Marco Brambilla

    Radiation Oncology 2016 11:159

    Published on: 13 December 2016

  14. Research

    Stereoscopic X-ray imaging, cone beam CT, and couch positioning in stereotactic radiotherapy of intracranial tumors: preliminary results from a cross-modality pilot installation

    To assess the accuracy and precision of a fully integrated pilot installation of stereoscopic X-ray imaging and kV-CBCT for automatic couch positioning in stereotactic radiotherapy of intracranial tumors. Posi...

    Barbara Zollner, Christian Heinz, Sabrina Pitzler, Farkhad Manapov, Steffi Kantz, Maya Christine Rottler, Maximilian Niyazi, Ute Ganswindt, Claus Belka and Hendrik Ballhausen

    Radiation Oncology 2016 11:158

    Published on: 7 December 2016

  15. Research

    SBRT for centrally localized NSCLC – What is too central?

    Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of per...

    J. Roesch, C. Panje, F. Sterzing, F. Mantel, U. Nestle, N. Andratschke and M. Guckenberger

    Radiation Oncology 2016 11:157

    Published on: 3 December 2016

  16. Research

    Class solutions for SABR-VMAT for high-risk prostate cancer with and without elective nodal irradiation

    The purpose of this study is to find the optimal planning settings for prostate SABR-VMAT for high-risk prostate cancer patients irradiated to prostate only (PO) or prostate and pelvic lymph nodes (PPLN).

    Sarah O. S. Osman, Prakash Jeevanandam, Nithya Kanakavelu, Denise M. Irvine, Ciara A. Lyons, Suneil Jain, Alan R. Hounsell and Conor K. McGarry

    Radiation Oncology 2016 11:155

    Published on: 24 November 2016

  17. Research

    MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells

    In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki

    Radiation Oncology 2016 11:153

    Published on: 22 November 2016

  18. Research

    Contribution of submandibular gland and swallowing structure sparing to post-radiation therapy PEG dependence in oropharynx cancer patients treated with split-neck IMRT technique

    Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of thi...

    Michael F. Gensheimer, Matthew Nyflot, George E. Laramore, Jay J. Liao and Upendra Parvathaneni

    Radiation Oncology 2016 11:151

    Published on: 15 November 2016

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