Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Research

    Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications

    To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast ir...

    Seung Hyuck Jeon, Kyung Hwan Shin, So-Yeon Park, Jung-in Kim, Jong Min Park, Jin Ho Kim, Eui Kyu Chie and Hong-Gyun Wu

    Radiation Oncology 2017 12:103

    Published on: 20 June 2017

  2. Research

    Intensity-modulated radiation therapy from 70Gy to 80Gy in prostate cancer: six- year outcomes and predictors of late toxicity

    To report grade ≥2 overall late rectal and urinary toxicities in patients (pts) with prostate cancer treated by intensity-modulated radiotherapy (IMRT) at 3 dose-levels. Identify predictors of radiation toxici...

    Maria Jolnerovski, Julia Salleron, Véronique Beckendorf, Didier Peiffert, Anne-Sophie Baumann, Valérie Bernier, Sandrine Huger, Vincent Marchesi and Ciprian Chira

    Radiation Oncology 2017 12:99

    Published on: 16 June 2017

  3. Research

    Salvage robotic SBRT for local prostate cancer recurrence after radiotherapy: preliminary results of the Oscar Lambret Center

    Currently, there is no standard option for local salvage treatment for local prostate cancer recurrence after radiotherapy. Our objective was to investigate the feasibility and efficiency of Robotic Stereotact...

    Thomas Leroy, Thomas Lacornerie, Emilie Bogart, Philippe Nickers, Eric Lartigau and David Pasquier

    Radiation Oncology 2017 12:95

    Published on: 9 June 2017

  4. Research

    High-biologically effective dose palliative radiotherapy for a tumor thrombus might improve the long-term prognosis of hepatocellular carcinoma: a retrospective study

    This study aimed to highlight the type of tumor thrombus and identify the prognostic factors influencing the long-term survival outcomes in patients with hepatocellular carcinoma (HCC) having a tumor thrombus....

    Xiang-quan Kong, Ya-ping Dong, Jun-xin Wu, Jun-yan He, Yu-yin Le, Kai-xin Du, Qing-qin Peng and Jin-luan Li

    Radiation Oncology 2017 12:92

    Published on: 31 May 2017

  5. Research

    Prognostic analysis of radiation pneumonitis: carbon-ion radiotherapy in patients with locally advanced lung cancer

    Carbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pn...

    Kazuhiko Hayashi, Naoyoshi Yamamoto, Masataka Karube, Mio Nakajima, Naruhiro Matsufuji, Hiroshi Tsuji, Kazuhiko Ogawa and Tadashi Kamada

    Radiation Oncology 2017 12:91

    Published on: 30 May 2017

  6. Research

    Whole breast and regional nodal irradiation in prone versus supine position in left sided breast cancer

    Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole bre...

    Pieter Deseyne, Bruno Speleers, Wilfried De Neve, Bert Boute, Leen Paelinck, Tom Van Hoof, Joris Van de Velde, Annick Van Greveling, Chris Monten, Giselle Post, Herman Depypere and Liv Veldeman

    Radiation Oncology 2017 12:89

    Published on: 26 May 2017

  7. Research

    Seven fractions to deliver partial breast irradiation: the toxicity is Low

    To assess toxicity and clinical outcome, in breast cancer patients treated with external beam partial breast irradiation (PBI) consisting of 35 Gy in 7 daily fractions (5 Gy/fraction).

    Marco Trovo, Michele Avanzo, Lorenzo Vinante, Carlo Furlan, Francesco Fiorica, Tiziana Perin, Loredana Militello, Simon Spazzapan, Massimiliano Berretta, Rajesh Jena, Joseph Stancanello, Erica Piccoli, Mario Mileto, Elvia Micheli, Mario Roncadin and Samuele Massarut

    Radiation Oncology 2017 12:86

    Published on: 23 May 2017

  8. Review

    Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site – current status and challenges

    This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown pri...

    Jens Müller von der Grün, Aykut Tahtali, Shahram Ghanaati, Claus Rödel and Panagiotis Balermpas

    Radiation Oncology 2017 12:82

    Published on: 10 May 2017

  9. Research

    A comprehensive dosimetric study on switching from a Type-B to a Type-C dose algorithm for modern lung SBRT

    Type-C dose algorithms provide more accurate dosimetry for lung SBRT treatment planning. However, because current dosimetric protocols were developed based on conventional algorithms, its applicability for the...

    Christina Zhou, Nathan Bennion, Rongtao Ma, Xiaoying Liang, Shuo Wang, Kristina Zvolanek, Megan Hyun, Xiaobo Li, Sumin Zhou, Weining Zhen, Chi Lin, Andrew Wahl and Dandan Zheng

    Radiation Oncology 2017 12:80

    Published on: 5 May 2017

  10. Research

    Does age really matter? Radiotherapy in elderly patients with glioblastoma, the Munich experience

    Glioblastoma is usually diagnosed around the age of 60–70 years. Patients older than 65 years are frequently described as “elderly”. Several trials with monotherapy have established treatment regimens that off...

    Christoph Straube, Hagen Scherb, Jens Gempt, Stefanie Bette, Claus Zimmer, Friederike Schmidt-Graf, Jürgen Schlegel, Bernhard Meyer and Stephanie E. Combs

    Radiation Oncology 2017 12:77

    Published on: 28 April 2017

  11. Research

    Setup errors in patients with head-neck cancer (HNC), treated using the Intensity Modulated Radiation Therapy (IMRT) technique: how it influences the customised immobilisation systems, patient’s pain and anxiety

    In patients with head-neck cancer treated with IMRT, immobility of the upper part of the body during radiation is maintained by means of customised immobilisation devices.

    Massimiliano Contesini, Monica Guberti, Roberta Saccani, Luca Braglia, Cinzia Iotti, Andrea Botti, Emilio Abbati and Marina Iemmi

    Radiation Oncology 2017 12:72

    Published on: 27 April 2017

  12. Research

    A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer

    Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggest...

    Caspar M. van Leeuwen, Arlene L. Oei, Kenneth W. T. K. Chin, Johannes Crezee, Arjan Bel, Anneke M. Westermann, Marrije R. Buist, Nicolaas A. P. Franken, Lukas J. A. Stalpers and H. Petra Kok

    Radiation Oncology 2017 12:75

    Published on: 27 April 2017

  13. Research

    A matched-pair analysis comparing whole-brain radiotherapy with and without a stereotactic boost for intracerebral control and overall survival in patients with one to three cerebral metastases

    Twelve years ago, a randomized trial demonstrated that a radiosurgery boost added to whole-brain radiotherapy (WBRT) improved intracerebral control (IC) in patients with one to three cerebral metastases. Overa...

    Dirk Rades, Stefan Janssen, Amira Bajrovic, Mai Trong Khoa, Theo Veninga and Steven E. Schild

    Radiation Oncology 2017 12:69

    Published on: 24 April 2017

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