Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Research

    A matched-pair analysis comparing whole-brain radiotherapy with and without a stereotactic boost for intracerebral control and overall survival in patients with one to three cerebral metastases

    Twelve years ago, a randomized trial demonstrated that a radiosurgery boost added to whole-brain radiotherapy (WBRT) improved intracerebral control (IC) in patients with one to three cerebral metastases. Overa...

    Dirk Rades, Stefan Janssen, Amira Bajrovic, Mai Trong Khoa, Theo Veninga and Steven E. Schild

    Radiation Oncology 2017 12:69

    Published on: 24 April 2017

  2. Research

    Long-term follow-up after stereotactic radiosurgery of intracanalicular acoustic neurinoma

    The management of solely intracanalicular acoustic neurinoma (iAN) includes observation, microsurgical resection and radiation therapy. Treatment goals are long-term tumor control, hearing preservation and con...

    Daniel Rueß, Lea Pöhlmann, Stefan Grau, Christina Hamisch, Alexandra Hellerbach, Harald Treuer, Martin Kocher and Maximilian I. Ruge

    Radiation Oncology 2017 12:68

    Published on: 21 April 2017

  3. Research

    Subventricular zones: new key targets for glioblastoma treatment

    We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma.

    J. Khalifa, F. Tensaouti, A. Lusque, B. Plas, J.-A. Lotterie, A. Benouaich-Amiel, E. Uro-Coste, V. Lubrano and E. Cohen-Jonathan Moyal

    Radiation Oncology 2017 12:67

    Published on: 20 April 2017

  4. Research

    Tumor motion changes in stereotactic body radiotherapy for liver tumors: an evaluation based on four-dimensional cone-beam computed tomography and fiducial markers

    For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning...

    Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya and Fujio Araki

    Radiation Oncology 2017 12:61

    Published on: 23 March 2017

  5. Research

    A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy

    To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the ...

    Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin and An-Cheng Shiau

    Radiation Oncology 2017 12:55

    Published on: 20 March 2017

  6. Research

    A phase II study of concurrent chemoradiotherapy combined with a weekly paclitaxel and 5-fluorouracil regimen to treat patients with advanced oesophageal carcinoma

    A phase II study was performed to investigate the safety and efficacy of weekly doses of combined paclitaxel and 5-fluorouracil (5-FU) with concurrent radiation therapy, followed by 2 cycles of consolidation c...

    Yi Xia, Yun-hai Li, Yun Chen, Jun-hua Zhang, Qi Liu, Jia-ying Deng, Ta-shan Ai, Han-ting Zhu, Jian-hong Fan, Harun Badakhshi and Kuai-le Zhao

    Radiation Oncology 2017 12:47

    Published on: 7 March 2017

  7. Research

    Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer

    Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy. This study investigated the treatment efficacy and toxicity of neoadjuva...

    Chun-Ming Huang, Ming-Yii Huang, Cheng-Jen Ma, Yung –Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Chih-Jen Huang and Jaw-Yuan Wang

    Radiation Oncology 2017 12:48

    Published on: 7 March 2017

  8. Research

    Fully automated treatment planning of spinal metastases – A comparison to manual planning of Volumetric Modulated Arc Therapy for conventionally fractionated irradiation

    Planning for Volumetric Modulated Arc Therapy (VMAT) may be time consuming and its use is limited by available staff resources. Automated multicriterial treatment planning can eliminate this bottleneck. We com...

    Daniel Buergy, Abdul Wahab M. Sharfo, Ben J. M. Heijmen, Peter W. J. Voet, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr and Florian Stieler

    Radiation Oncology 2017 12:33

    Published on: 31 January 2017

  9. Research

    Helical tomotherapy of spinal chordomas: French Multicentric, retrospective study of a cohort of 30 cases

    To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible.

    Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo and Guy Kantor

    Radiation Oncology 2017 12:32

    Published on: 31 January 2017

  10. Research

    Helical TomoTherapy for locally advanced or recurrent breast cancer

    We report our experience of using helical tomotherapy (HT) to treat large and irregular shaped loco-regional advanced breast cancer target volumes embracing various organs at risk.

    M. N. Duma, C. Heinrich, C. Schönknecht, B. Chizzali, M. Mayinger, M. Devecka, S. Kampfer and S. E. Combs

    Radiation Oncology 2017 12:31

    Published on: 28 January 2017

  11. Short report

    Short report: interim safety results for a phase II trial measuring the integration of stereotactic ablative radiotherapy (SABR) plus surgery for early stage non-small cell lung cancer (MISSILE-NSCLC)

    A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We rep...

    David A. Palma, Timothy K. Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V. Louie, Eric Frechette, George B. Rodrigues, Brian Yaremko, Edward Yu, A. Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner…

    Radiation Oncology 2017 12:30

    Published on: 27 January 2017

  12. Review

    Current controversies in radiotherapy for breast cancer

    Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative an...

    David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D. Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz and Rolf Sauer

    Radiation Oncology 2017 12:25

    Published on: 23 January 2017

  13. Review

    Intraoperative radiation therapy (IORT) in pancreatic cancer

    Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy re...

    Robert Krempien and Falk Roeder

    Radiation Oncology 2017 12:8

    Published on: 19 January 2017

  14. Review

    Intraoperative radiotherapy in gynaecological and genito-urinary malignancies: focus on endometrial, cervical, renal, bladder and prostate cancers

    Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in ...

    Marco Krengli, Carla Pisani, Letizia Deantonio, Daniela Surico, Alessandro Volpe, Nicola Surico and Carlo Terrone

    Radiation Oncology 2017 12:18

    Published on: 19 January 2017

  15. Review

    Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

    Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectivenes...

    Carsten Herskind, Lin Ma, Qi Liu, Bo Zhang, Frank Schneider, Marlon R. Veldwijk and Frederik Wenz

    Radiation Oncology 2017 12:24

    Published on: 19 January 2017

  16. Research

    The use of dose-escalated radiation for locally advanced non-small cell lung cancer in the U.S., 2004–2013

    The clinical effects of radiation dose-intensification in locally advanced non-small cell lung (NSCLCa) and other cancers are challenging to predict and are ideally studied in randomized trials. The purpose of...

    John P. Christodouleas, Matthew D. Hall, Marjorie A. van der Pas, Wensheng Guo, Timothy E. Schultheiss and Peter Gabriel

    Radiation Oncology 2017 12:19

    Published on: 17 January 2017

  17. Research

    Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer

    In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could pr...

    Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Haruna Nishimaki and Shinobu Masuda

    Radiation Oncology 2017 12:16

    Published on: 13 January 2017

  18. Research

    Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer

    Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...

    Matthew J. Boyer, Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu and W. Robert Lee

    Radiation Oncology 2017 12:14

    Published on: 13 January 2017

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